Case Study: Enhancing Mitochondrial Function Using Lumati’s 5-in-1 Recharge Station

Lumati Team
Jun 11
5 min read

Updated: Jun 23

Introduction: The Role of Mitochondrial Dominance in Health and Resilience

Mitochondrial health is at the heart of human performance, recovery, and longevity.

When the body primarily relies on efficient, oxygen-based energy production (known as oxidative phosphorylation), it’s said to be in a state of mitochondrial dominance. This is the optimal state—producing more energy (ATP) with fewer harmful byproducts.

The Lumati 5-in-1 Recharge Station was designed to help restore the body’s natural energy balance by supporting optimal mitochondrial function. It does this by targeting multiple key biological systems at once.

This case study evaluates how the 5-in-1 system impacts mitochondrial performance over a 30-day period, using a clinically validated blood test developed by researchers at UC San Diego and NASA.

I. Study Design & Methodology

Participant Profile

Male, 52 years old
Physically active; no major comorbidities
Reported symptoms: mid-afternoon energy dips, delayed post-exertion recovery

Controls and Conditions

To reduce confounding variables:

No changes to diet, exercise, sleep schedule, supplement regimen, or travel/work schedule for 30 days
The participant did not introduce any new stressors, medications, or therapeutic modalities

Intervention

Duration: 30 days
Protocol: 3 sessions per week, 15 minutes per session
Device: Lumati 5-in-1 Recharge Station (5 modalities used concurrently)

II. Mitochondrial Biomarker Analysis via mescreen™

What is mescreen™?

The mescreen Mitochondrial Function Blood Test, developed by Dr. Hemal Patel’s research group at UC San Diego in partnership with NASA, is a validated system that assesses mitochondrial activity and metabolic energy balance from a single blood sample.

It evaluates:

Mitochondrial Energy Score (0–100)
- Quantifies the cell’s ability to produce energy through oxidative phosphorylation
Energy Pathway Ratio (Mitochondrial vs. Non-Oxidative)
- Measures relative reliance on mitochondrial vs. glycolytic metabolism
- Higher values indicate a dominance of clean, oxygen-based energy metabolism

mescreen leverages mass spectrometry and machine learning to analyze metabolomic and proteomic markers. These include mitochondrial membrane potential, NAD⁺/NADH ratios, and additional indicators of downstream energetic efficiency.

III. Results

Metric	Baseline (Day 0)	Post-Intervention (Day 30)
Mitochondrial Energy Score	38 (Suboptimal)	51 (Optimal range)
Mito/Non-Oxidative Ratio	70 (Low efficiency)	145 (High efficiency)

Interpretation:

+34% improvement in mitochondrial ATP production capacity
+107% shift toward mitochondrial energy dominance over glycolytic reliance

These results suggest a significant biological response to the 5-in-1 protocol over a short intervention period—indicative of improved cellular efficiency and metabolic resilience.

The data below reflects the subject’s results at Day Zero (prior to using the 5-in-1) and at Day 30, following three sessions per week, as measured by the mescreen blood test and processed by a third-party lab.

Day Zero Report

Mitochondrial Energy

A low Mitochondrial Energy means you struggle with stress and recovery. After exercise or stress, it takes longer to bounce back. This might make you feel tired and uncomfortable as your body's stress management lags.

low: 0-45 | optimal: 46-64 | high: 65-100

Optimal Energy Ratio (Mitochondrial/Glycolysis)

Your body is relying more on glycolysis, a fast but less efficient way of producing energy. This can lead to energy spikes and crashes, increased lactate production, and cellular stress over time. While glycolysis is helpful in short bursts or under stress, chronic dependence may reflect mitochondrial underperformance.

low: 0-99 | average: 100 - 120 | optimal: 121 +

Day 30 Report

Mitochondrial Energy

An optimal Mitochondrial Energy shows that your cells handle mild stress well. Your body copes with exercise and stress in a balanced way. This moderate approach keeps you resilient and functional.

low: 0-45 | optimal: 46-64 | high: 65-100

Optimal Energy Ratio (Mitochondrial/Glycolysis)

Your body prioritizes mitochondrial energy production, the most efficient and sustainable energy pathway. This is a strong indicator of cellular health, metabolic flexibility, and long-term energy stability. Individuals in this range often experience better endurance, clearer mental focus, and less fatigue.

low: 0-99 | average: 100-120 | optimal: 121 +

IV. Mechanisms of Action: Enhancing Mitochondrial Function Using Lumati’s 5-in-1 Recharge Station

Modality	Mechanism	Key Literature
Red Light Therapy	Stimulates cytochrome c oxidase, increases ATP, biogenesis	Hamblin, 2016
Micro-Impact Plate	Activates nitric oxide, circulation, bone density, mitochondria	Lau et al., 2012
Hydrogen Inhalation	Selectively reduces hydroxyl radicals, enhances mitochondrial signaling	Ohta, 2012
Vagal Audio Stimulation	Activates parasympathetic tone, lowers cortisol, enhances repair	Tracey, 2007
Nanosomal Curcumin	Inhibits NF-κB, supports mitochondrial enzyme activity	Aggarwal, 2007; Yoshino et al., 2011

These interventions are synergistic, collectively targeting redox homeostasis, mitochondrial membrane potential, inflammation control, and neural recovery pathways.

VI. Implications for Healthspan and Aging

This study supports existing literature linking mitochondrial efficiency with healthy aging. Improved mitochondrial performance affects:

AMPK/SIRT1 Activation: Pathways for cellular repair and autophagy
Metabolic Flexibility: Efficient fuel switching from glucose to fat
ROS Reduction: Lower chronic inflammation via Nrf2 pathway
Neuroprotection: Increased brain resilience through enhanced energy availability

These shifts align with the Hallmarks of Aging (López-Otín et al., 2013), positioning the 5-in-1 as a multi-modal intervention capable of addressing cellular senescence, metabolic deregulation, and mitochondrial dysfunction simultaneously.

VII. Limitations and Future Directions

Single-Subject (n=1): Results are not generalizable but provide a promising framework for expanded trials
Need for Longitudinal Follow-Up: Sustainability of changes over time are now being tested
Next Steps:
- Expand to n=10–30 with diverse age and health backgrounds
- Include salivary cortisol, heart rate variability, and lactate clearance metrics
- Pair with continuous glucose monitors or metabolic carts for deeper metabolic insight
- Capture data at 60 and 90 day marks with continued device adherence, then measure the following 30, 60 and 90 days with no device usage to see how long performance is maintained

Conclusion

This 30-day case study showed clear, measurable improvements in mitochondrial function using the Lumati 5-in-1 Recharge Station—a time-efficient, multimodal therapeutic approach. The participant experienced:

34% improvement in Mitochondrial Energy Score
107% shift toward mitochondrial energy dominance
Subjective gains in energy, clarity, recovery, and mood

Remarkably, these results were achieved with just 45 minutes of treatment per week—accomplishing in one month what often takes several through lifestyle changes alone.

Scientifically grounded and highly efficient, the 5-in-1 Recharge Station offers a promising pathway for performance enhancement, longevity, and healthier aging.

References

Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys.2017
Ohta S. Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. Methods Enzymol. 2015
Wallace DC. Mitochondria and cancer. Nat Rev Cancer. 2012
Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016
López-Otín C, et al. The hallmarks of aging. Cell. 2013
Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010
Lau RW, et al. The effects of whole body vibration on bone mineral density in older adults: a systematic review. J Musculoskelet Neuronal Interact. 2011
Tracey KJ. Reflex control of immunity. Nat Rev Immunol. 2009